Liebe Leser, hier finden Sie die Übersicht aller in unserem Buch „Cannabis und Cannabidiol (CBD) richtig anwenden“ zitierten Studien – sortiert nach den jeweiligen Heilanzeigen.
Abhängigkeit von Medikamenten oder Alkohol
Medical cannabis and mental health: A guided systematic review” by Zach Walsh, Raul Gonzalez, Kim Crosby, Michelle S. Thiessen, Chris Carroll, and Marcel O. Bonn-Miller Clinical Psychology Review. Published online November 2016
Ängste
Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG. Action of cannabidiol on theanxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl). 1982;76(3):245-50
Zuardi AW, Cosme RA, Graeff FG, Guimarães FS. Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharmacol. 1993 Jan;7(1 Suppl):82-8
Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ. Cannabidiol enhances consolidation of explicit fear extinction in humans. Psychopharmacology (Berl). 2013 Apr;226(4):781-92
Appetitlosigkeit und Auszehrung
Brisbois TD, de Kock IH, Watanabe SM, et al. Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. Ann Oncol. 2011;22:2086–93
Haney M, Rabkin J, Gunderson E, Foltin RW. Dronabinol and marijuana in hiv+ marijuana smokers: acute effects on caloric intake and mood. Psychopharmacology (Berl) 2005;181:170–8
Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ. Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 1997;12:913–19
Asthma
Gong H Jr, Tashkin DP, Calvarese B. Comparison of bronchial effects of
nabilone and terbutaline in healthy and asthmatic subjects. J Clin Pharmacol.
1983 Apr;23(4):127-33
Tashkin DP, Shapiro BJ, Lee YE, Harper CE. Effects of smoked marijuana in
experimentally induced asthma. Am Rev Respir Dis. 1975 Sep;112(3):377-86
Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS)
Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P. Cannabinoids
in attention-deficit/hyperactivity disorder: A randomised-controlled trial. Eur
Neuropsychopharmacol. 2017 Aug;27(8):795-808is. 1975 Sep;112(3):377-86
Darmerkrankungen (chronisch entzündliche)
De Filippis D, Esposito G, Cirillo C, Cipriano M, De Winter BY, Scuderi C,
Sarnelli G, Cuomo R, Steardo L, De Man JG, Iuvone T. Cannabidiol reduces
intestinal inflammation through the control of neuroimmune axis. PLoS One.
2011;6(12)
Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F,
Konikoff FM. Cannabis induces a clinical response in patients with Crohn’s
disease: a prospective placebo-controlled study. Clin Gastroenterol Hepatol. 2013 Oct;11(10):1276-1280
Diabetes
Selvarajah D, Gandhi R, Emery CJ, Tesfaye S. Randomized placebo-controlled
double-blind clinical trial of cannabis-based medicinal product (Sativex) in
painful diabetic neuropathy: depression is a major confounding factor. Diabetes
Care. 2010 Jan;33(1):128-30
Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH. Efficacy of Inhaled
Cannabis on Painful Diabetic Neuropathy. J Pain. 2015 Jul;16(7):616-27
Entzündliche Gelenkerkrankung (Arthritis)
D. R. Blake, P. Robson, M. Ho, R. W. Jubb, C. S. McCabe; Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis, Rheumatology, Volume 45, Issue 1, 1 January 2006, Pages 50–52
Epilepsie
Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I,
Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund
J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR.
Cannabidiol in patients with treatment-resistant epilepsy: an open-label
interventional trial. Lancet Neurol. 2016 Mar;15(3):270-8
Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE,
Thiele EA, Wright S; Cannabidiol in Dravet Syndrome Study Group. Trial of
Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med.
2017 May 25;376(21):2011-2020
Fibromyalgie
Ste-Marie PA, Fitzcharles MA, Gamsa A, Ware MA, Shir Y. Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia.
Arthritis Care Res (Hoboken). 2012 Aug;64(8):1202-8
Skrabek RQ, Galimova L, Ethans K, Perry D. Nabilone for the treatment of pain in fibromyalgia. J Pain. 2008 Feb;9(2):164-73
Ware MA, Fitzcharles MA, Joseph L, Shir Y. The effects of nabilone on sleep infibromyalgia: results of a randomized controlled trial. Anesth Analg. 2010 Feb
1;110(2):604-10
Grüner Star (Glaukom)
Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. Effect of
sublingual application of cannabinoids on intraocular pressure: a pilot study. J
Glaucoma. 2006 Oct;15(5):349-53
Krebs
Guzman M, Duarte MJ, Blazquez C, Ravina J, Rosa MC, Galve-Roperh I, Sanchez C, Velasco G, Gonzalez-Feria L. A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer, 27. Juni 2006
Multiple Sklerose (MS)
Leocani L, Nuara A, Houdayer E, Schiavetti I, Del Carro U, Amadio S, Straffi
L, Rossi P, Martinelli V, Vila C, Sormani MP, Comi G. Sativex(®) and
clinical-neurophysiological measures of spasticity in progressive multiple
sclerosis. J Neurol. 2015 Nov;262(11):2520-7
Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe
S. A double-blind, randomized, placebo-controlled, parallel-group study of
THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. J
Neurol. 2013 Apr;260(4):984-97
Serpell MG, Notcutt W, Collin C. Sativex long-term use: an open-label trial in
patients with spasticity due to multiple sclerosis. J Neurol. 2013
Jan;260(1):285-95
Müdigkeit
Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of
Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004 Jun;24(3):305-13
Neurodermitis (atopisches Ekzem)
James Callaway et al: Efficacy of dietary hempseed oil in patients with atopic dermatitis, Journal of Dermatological Treatment Volume 16, 2005 – Issue 2
Liszewski W, Farah RS. Response to: „The role of cannabinoids in dermatology“.
J Am Acad Dermatol. 2017 Sep;77(3):e87-e88
Parkinson-Krankheit
Lotan I, Treves TA, Roditi Y, Djaldetti R. Cannabis (medical marijuana)
treatment for motor and non-motor symptoms of Parkinson disease: an open-label
observational study. Clin Neuropharmacol. 2014 Mar-Apr;37(2):41-4
Balash Y, Bar-Lev Schleider L, Korczyn AD, Shabtai H, Knaani J, Rosenberg A,
Baruch Y, Djaldetti R, Giladi N, Gurevich T. Medical Cannabis in Parkinson
Disease: Real-Life Patients‘ Experience. Clin Neuropharmacol. 2017
Nov/Dec;40(6):268-272
Posttraumatische Belastungsstörung (PTBS)
Cameron C, Watson D, Robinson J. Use of a synthetic cannabinoid in a
correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: a retrospective evaluation. J Clin Psychopharmacol. 2014 Oct;34(5):559-64
Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A. Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Clin Drug Investig. 2014 Aug;34(8):587-91
Psoriasis (Schuppenflechte)
Wilkinson JD, Williamson EM. Cannabinoids inhibit human keratinocyte
proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic
value in the treatment of psoriasis. J Dermatol Sci. 2007 Feb;45(2):87-92
Raucherentwöhnung
Morgan CJ, Das RK, Joye A, Curran HV, Kamboj SK. Cannabidiol reduces cigarette
consumption in tobacco smokers: preliminary findings. Addict Behav. 2013
Sep;38(9):2433-6
Reizdarmsyndrom
Russo EB. Clinical Endocannabinoid Deficiency Reconsidered: Current Research
Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other
Treatment-Resistant Syndromes. Cannabis Cannabinoid Res. 2016 Jul 1;1(1):154-165
Restless-Legs-Syndrom
Megelin T, Ghorayeb I. Cannabis for restless legs syndrome: a report of six
patients. Sleep Med. 2017 Aug;36:182-183
Schizophrenie
Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J,
Hellmich M, Koethe D. Cannabidiol enhances anandamide signaling and alleviates
psychotic symptoms of schizophrenia. Transl Psychiatry. 2012 Mar 20;2:e94
Schmerzen
Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH. Efficacy of Inhaled
Cannabis on Painful Diabetic Neuropathy. J Pain. 2015 Jul;16(7):616-27
Wilsey B, Marcotte T, Deutsch R, Gouaux B, Sakai S, Donaghe H. Low-dose
vaporized cannabis significantly improves neuropathic pain. J Pain. 2013
Feb;14(2):136-48
Ware MA, Wang T, Shapiro S, Robinson A, Ducruet T, Huynh T, Gamsa A, Bennett GJ, Collet JP. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ. 2010 Oct 5;182(14):E694-701
Rhyne DN, Anderson SL, Gedde M, Borgelt LM. Effects of Medical Marijuana on
Migraine Headache Frequency in an Adult Population. Pharmacotherapy. 2016
May;36(5):505-10
Schlafapnoe-Syndrom
Carley DW, Prasad B, Reid KJ, Malkani R, Attarian H, Abbott SM, Vern B, Xie H,
Yuan C, Zee P. Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE
Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea. Sleep. 2017 Nov
7. doi: 10.1093/sleep/zsx184
Tourette-Syndrom
Müller-Vahl KR, Schneider U, Prevedel H, Theloe K, Kolbe H, Daldrup T, Emrich
HM. Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. J Clin Psychiatry. 2003 Apr;64(4):459-65
Müller-Vahl KR, Schneider U, Kolbe H, Emrich HM. Treatment of Tourette’s
syndrome with delta-9-tetrahydrocannabinol. Am J Psychiatry. 1999 Mar;156(3):495
Tumorschmerzen
Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S,
McQuade R, Wright S, Fallon MT. Nabiximols for opioid-treated cancer patients
with poorly-controlled chronic pain: a randomized, placebo-controlled,
graded-dose trial. J Pain. 2012 May;13(5):438-49
Übelkeit und Erbrechen
Delta-9-tetrahydrocannabbinol as an antiemetics for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. Von Frytak, Moertel, O´Fallon, Rubin, Creagan, O´Connel im Ann Int Med 1070; 91: S. 825-830
Duran M, Pérez E, Abanades S, Vidal X, Saura C, Majem M, Arriola E, Rabanal M,
Pastor A, Farré M, Rams N, Laporte JR, Capellà D. Preliminary efficacy and safety
of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. Br J Clin Pharmacol. 2010 Nov;70(5):656-63
Beal JE, Olson R, Laubenstein L, Morales JO, Bellman P, Yangco B, Lefkowitz L,
Plasse TF, Shepard KV. Dronabinol as a treatment for anorexia associated with
weight loss in patients with AIDS. J Pain Symptom Manage. 1995 Feb;10(2):89-97
Verletzungen
Nguyen BM, Kim D, Bricker S, Bongard F, Neville A, Putnam B, Smith J, Plurad D. Effect of marijuana use on outcomes in traumatic brain injury. Am Surg. 2014 Oct;80(10):979-83
Pooyania S, Ethans K, Szturm T, Casey A, Perry D. A randomized,
double-blinded, crossover pilot study assessing the effect of nabilone on
spasticity in persons with spinal cord injury. Arch Phys Med Rehabil. 2010
May;91(5):703-7